Humphreys is a village in southwest Sullivan County, Missouri, United States.

[5] According to the United States Census Bureau, the village has a total area of 0.25 square miles (0.65 km2), all land.

The town experienced rapid early growth, being located on the Quincy, Missouri & Pacific Railroad, with the train depot being constructed in August 1881.

The citizenry's need for news was met by the Humphreys Gazette, a weekly newspaper founded in late 1881 by Joseph S. Wright.

The name was changed to the Humphreys Advance in 1884 but the venture ultimately proved unprofitable and publication ceased in August 1887.

The children of Humphreys were educated in a typical one-room rural schoolhouse, located about three-fourths of a mile northwest of the community until 1885.

At that time, the elementary and secondary education were combined with and housed in the building containing the Humphreys College and Business Institute.

Humphreys College was co-education and offered two course tracks of study—preparatory and collegiate, with a reported enrollment in 1887 of 157 students.

No dormitories were constructed; however, ample housing was available in the town's hotels and private homes.

[9] Humphreys College and Business Institute was completely destroyed by fire on April 8, 1893.

Most citizens must travel to larger cities in the region such as Milan, Trenton, Brookfield and Kirksville for employment.

Presently, children from Humphreys attend Grundy County R-5 school in Galt.