On 7 December 1870, the Austro–Hungarian Empire and Uruguay signed a Trade, Shipping and Friendship Treaty.

[2] There was also an important influx of Hungarian Jews to Uruguay during the first half of the 20th century.

[5] Initial high-level visits between foreign ministers took place in 1972 when Hungarian Deputy Foreign Minister, Imre Hollai, paid a visit to Uruguay.

In 1986, Uruguayan Foreign Minister, Enrique V. Iglesias, paid a visit to Hungary.

In 2002, Uruguay closed its embassy in Budapest due to budget restraints.