With the outbreak of the Young Turk Revolution in 1908, President of the United States Theodore Roosevelt named Wilson Envoy Extraordinary and Minister Plenipotentiary to the Ottoman Empire.
Knox, in addition to being ignorant of foreign affairs, was very lax about his official duties, and Wilson was, in his own words, "frequently left in charge of the Department for months at a time.
Wilson attempted to retire due to factors inside the State Department but was persuaded to remain for another two years.
He also began writing books at this time, with his published titles including Stultitia (1914), The Peril of Hifalutin (1918), Money and the Price Level (1932), and Memoirs of an Ex-Diplomat (1945).
Wilson married his third wife, Hope Butler of New York City, in 1925.