The Times formerly operated as an afternoon paper, but moved to mornings years after The Huntsville News ceased publication.

[2] Because Huntsville is the home to NASA's Marshall Space Flight Center and the Army's Redstone Arsenal, the Times maintained a special desk for science, aerospace and military matters.

[3] The Times received many awards over the years from the Alabama Press Association, the Society for Professional Journalists and other trade groups.

On November 3, 2022, Advance management announced that the Times, as well as its sister newspapers in Birmingham and Mobile, would discontinue its print edition and convert to an all-digital operation.

Patrick McCauley, a native of Alexandria, Louisiana, was the longest-serving editor of the daily Huntsville Times, a post he filled from 1966 to 1994.