Hurler–Scheie syndrome is a genetic disorder caused by the buildup of glycosaminoglycans (GAGs) in various organ tissues.

It is a cutaneous condition, also characterized by mild mental retardation and corneal clouding.

[2] Respiratory problems, sleep apnea, and heart disease may develop in adolescence.

Patients with Hurler–Scheie syndrome lack the ability to break down GAGs in their lysosomes due a deficiency of the enzyme iduronidase.

[citation needed] All forms of mucopolysaccharidosis type I (MPS I) are a spectrum of the same disease.