Hussein Nagi Khairan (Arabic: حسين ناجي خيران, romanized: Ḥusayn Nājī Khyrān) is a Yemeni military officer.

Until November 2016, he served as defense minister for the Houthi-appointed government of Yemen, having been appointed on 22 March 2015, after the defection of Mahmoud al-Subaihi to the internationally recognised government of Abd Rabbuh Mansur Hadi in Aden.

According to a Houthi political official, Khairan's appointment placed him in direct command of all military units except for those loyal to Hadi.

[3] However, the Houthi militants that occupied Sana'a earlier that year blocked him from entering the defense ministry.

[4] Hadi officially fired Khairan as army chief of staff on 5 April, weeks after he switched sides to join the Houthis' ranks.