Directed by Emmanuel Q. Palo, Darnel Joy R. Villaflor, Jerry Lopez Sineneng and Ram Tolentino, it stars Andrea Brillantes, Francine Diaz, Kyle Echarri and Seth Fedelin.

[1][2] It premiered on March 22, 2021 on the network's Primetime Bida line up replacing Ang sa Iyo ay Akin.

But on one night, a fire burnt down the town church, while the parish priest was killed for a golden, bejewelled votive crown.

At this time, a statue of Jesus Christ, whom they call "Bro", comes alive in an apparition and orders them to rebuild the church and restore the town’s faith in God.

Against all odds and the godless in the community, Mira and Joy follow "Bro", inspiring the people of Hermoso to return to their faith.

Meanwhile, taking advantage of the town's superstitious residents, and anticipating a lucrative source of income, Deborah claims the miracles are due to her healing powers, including Mira's restored sight.

As more genuine miracles occur around Joy and Mira, Deborah steals credit even as the sisters insist the wonders are all from "Bro".

This enrages Deborah, as the girls’ campaign to rebuild the town church competes with her cult activities and “healing dome”.

Though devastated, Barang and the girls overcome more challenges as they seek justice for Fátima, and struggle with the evil gripping Hermoso, all while winning hearts for “Bro”.

As many slowly turn to “Bro”, the town’s transformation from godlessness unfolds into a beautiful story of faith, forgiveness, and redemption.

Huwag Kang Mangamba re-aired the first 8 episodes as Huwag Kang Mangamba: The Holy Week Special on Good Friday, April 2, 2021, at 6:00 p.m. on Kapamilya Channel and Kapamilya Online Live and on A2Z on Black Saturday, April 3, 2021, at 2:00 p.m.[17] Ian Veneracion was originally cast to play the role of Elias, but he backed out of this show because of scheduling conflicts for the upcoming new season.