It is the terminus for several CCRTA bus lines and its CapeFLYER passenger train that operates on summer weekends between Boston South Station and Hyannis.

The New Haven Railroad used a separate station 1.0 mile (1.6 km) north from 1953 until passenger service ended in 1964.

The first Hyannis station was constructed in the early 1850s by the Cape Cod Railroad in time for the arrival of the first train from Boston on July 8, 1854.

[1] Tracks continued 1.6 miles (2.6 km) south to Hyannis Wharf, where ferries connected to Martha's Vineyard and Nantucket Island.

[7][8] In July 1981, the Cape Cod Central Railroad began summer-only excursion service between Hyannis and Sandwich.

[2] The station platform on the east side of the mainline is approximately 645 feet (197 m) long, which accommodates a seven car train.

[9] The larger Hyannis Transportation Center (HTC) was constructed just to the north in 2002, with a platform on the opposite side of the same track.