Application for the first Hygiene Post Office was made by Jacob Stoner Flory of the United Church of the Brethren on May 28, 1883.

Jacob S. Flory, a Virginian Church of the Brethren (also known as "German Baptist") minister, arrived in the Pella area in 1873 with his wife and eight children, establishing the St. Vrain congregation there in 1877.

The three-story, 35-room house was sought by patients who hoped the area's "clean, mountain air, low humidity, high elevation, and year-round sunshine" would help them recover; roughly one-third of Colorado's population in 1900 were those seeking tuberculosis treatment.

However, the woes of the First World War and Great Depression saw the congregation struggle; often, ministers had to again be shared with Lyons or Longmont.

[12][13] The BNSF Railway has trackage on the south edge of Hygiene which is a branch line connecting Longmont and the Cemex cement plant at Lyons.