It was named for its "prolific" number of stamens.

[4] Hypericum prolificum is a shrub growing up to 2 m (6 ft 7 in) tall with elliptic to oblanceolate leaves up to 70 mm (2.8 in) long and 15 mm (0.59 in) broad.

[5] The flowerheads have between 1 and 9 flowers, each 15–30 mm (0.59–1.18 in) across with 5 golden yellow petals and numerous stamens.

[5] Hypericum prolificum is native to the central and eastern United States and Ontario.

[3][6] Habitats include riparian areas, slopes, thickets, swamp edges, and oak woodlands.