The Hypsiprymnodontidae /ˌhɪpsɪˌprɪmnoʊdɒnˈtaɪdiː/ are a family of macropods, one of two families containing animals commonly referred to as rat-kangaroos.

The single known extant genus and species in this family, the musky rat-kangaroo, Hypsiprymnodon moschatus, occurs in northern Australia.

During the Pleistocene, this family included the megafauna genus Propleopus.

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