Shinobu Nakagawa is a newly licensed pediatrician employed at the fictional St. Michael's General Hospital in Tokyo, Japan.

[3] Upon his arrival, Shinobu receives the proposition to fill-in for a sick professor at the Saint Michael's Nursing School; an all-girls institution near the hospital.

While each one, including Shinobu's own foster family, harbor amorous feelings for him, only through careful judgment will one particular woman outstand the rest and win his heart.

Kango Shicyauzo is played like a traditional visual novel; the player advances through scenes with character dialog, and making decisions based on scripted dilemmas which occur.

Gameplay selections branch to different plotlines, usually leading to Shinobu monogamously dating, sexually engaging, and marrying one of the primary female cast members.

If however, the player fails to establish a relationship, Shinobu will be called back to mandatorily work at the hospital; thus, ending the game early.