[5][6] This gene is a member of the Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain.

The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma.

Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.

Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

This article on a gene on human chromosome 7 is a stub.