INVAP was created on September 1, 1976,[2] as a spin-off of the Argentine Atomic Energy Commission, research laboratories division.

INVAP was the first company in Latin America to provide design, development, mission control and operational support.

[3] The SAC-D was put into orbit on June 9, 2011, carrying several scientific payloads, including NASA's $100 million Aquarius project, which will measure the oceans' salinity.

[10] In 2010, INVAP and CITEDEF completed the development and readied for testing a method that used a laser to remove the radioactive components from heavy water which is used to cool nuclear reactors.

[11] On the 24th of January, 2018, INVAP won the international tender for a nuclear research reactor and radioisotope production facility for medical uses in The Netherlands.