The People Mover ceased operation in February 2019 due to high maintenance costs and was replaced by an extensive shuttle bus system that offers transport between the three downtown hospitals.

[16] At the same time, IU Health added physicians’ offices and opened multiple urgent care centers.

[17] In 2016, IU Health announced it would move women's services including maternity care from its Methodist campus to Riley Hospital for Children.

In 2022, IU Health announced plans to construct a new flagship facility to consolidate University and Methodist hospitals with an expected cost of $4.3 billion, one of the most expensive capital projects ever undertaken in Indiana state history.

[23] Of 98 academic medical centers included in the analysis, IU Health Methodist Hospital is one of five to earn the Quality Leadership Award.

Academic Medical Centers were assessed across a broad spectrum of care including safety, timeliness, effectiveness, efficiency, equity and patient-centeredness.

IU Health's Trauma Centers include multidisciplinary teams of board-certified physicians, nurses and technicians available onsite to treat the most severely injured patients at all times.

IU Health Arnett Hospital became Indiana's first level 3 verified trauma center in April 2013.