The walls are built with red brick in Flemish bonding style, and there is limestone detailing surrounding the windows and above the main entrance.

Large scale outbreaks such as Spanish Flu and polio led to a growing need for a greater health care system and long-term recovery services.

[3][4] The building was an important expansion for Riley as it funded by charity organizations during the height of the Great Depression in the United States, but also assisted with rising cases of seasonal polio amongst children in the Indianapolis area.

[7] The Speedway Flyer reported that this was one of the oldest known clinics specializing in cerebral palsy in Indiana and potentially the United States.

[9] In 2014, the Rotary Building would be renovated to expose the original terrace and rehabilitate the interior with modern amenities to meet current educational needs.

As of 2023[update], the Rotary Building hosts the Center for Global Health, Office of Medical Education, and divisions of pulmonology, gastroenterology, and hepatology.