The title I Against I presumably refers to the common Rastafarian phrase I and I, which is used in place of the first-person plural (i.e. we) to signify the union of the speaker, audience, and Jah (God) in love and peace.

[8][9] The Dillinger Escape Plan singer Greg Puciato named it one of the four albums that changed his life, as well as "a critical step" in shaping his vocal style.

[10][11] Max Cavalera of Sepultura states that the beginning of 1996 song "Straighthate" was probably inspired by "I Against I" since his band admired the Bad Brains.

"[15] Beppo of German punk band Spermbirds affirmed, "I Against I had a huge impact on us, they taught us that you can also be hard by playing slow.

[26] "Re-Ignition" has been sampled on "Daddy's Home" by Chubb Rock,[27] "Ice Man Cometh" by 2 Black 2 Strong MMG,[citation needed] "Ultrasonic Sound" by Hive (which later appeared on The Matrix soundtrack),[citation needed] and on a remix of the 2004 song "Roll Call" by Lil Jon and Ice Cube.