The film also features Julia Ormond, Neal McDonough, Brian Geraghty, Garcelle Beauvais and Spencer Garrett in supporting roles.

The film received negative media coverage during production and upon its release, as Lohan publicly struggled with drug addiction and other personal issues.

I Know Who Killed Me subsequently developed a cult following that has reexamined it as a modern giallo, and several screenings of it have been put together by historic theaters and film festivals.

The quiet suburb of New Salem is being terrorized by a serial killer who abducts and tortures young women, holding them captive for weeks before murdering them.

As the days tick by, the special FBI Task Force convened to track the killer begins to lose hope of finding him before it's too late.

Late one night, a driver discovers a young woman by the side of a deserted road, disheveled and seriously wounded, with one of her hands and legs amputated.

Convinced Aubrey is suffering from post-traumatic stress disorder, her doctors, parents, and law enforcement officials can only wait for rest and therapy to restore her memory.

Using her prosthetic hand, she smashes the front of the glass coffin that Norquist buried Aubrey in, revealing her barely alive in a white dress.

[6][11] Sivertson claimed that production "never lost any shooting days because of rehab," with Lohan declaring she drew from what she was personally experiencing to tackle some of the film's darker themes.

"[12] Before the release, Lohan admitted to being apprehensive about taking on the role and people's reception: "Yeah, it kind of fucked my head up a little bit, just because it was so intense.

"[15] In July 2007, Lohan was arrested for driving under the influence, which prevented her from doing promotion for the film, including its premiere event and a scheduled appearance on The Tonight Show with Jay Leno.

The art cover of the DVD shows Lohan, in blue, pole-dancing, with the faces of her alter egos Aubrey Fleming and Dakota Moss on either side.

[23] The Region 2 DVD was released January 28, 2008, with different cover art showing a close-up of Lohan, in red, doing her pole-dance at the strip club.

The website's consensus reads: "Distasteful and ludicrously plotted, I Know Who Killed Me is a career nadir for all involved – particularly Lindsay Lohan in a dual role".

"I Know Who Killed Me", a ridiculous thriller (minus the thrills) starring the embattled Lindsay Lohan in a dual role, has all the hallmarks necessary for qualification: A nonsensical plot that grows sillier by the second, tawdry special effects, heavy-handed symbolism that's big on electric-blue hues and mechanical performances are all culprits as far as the title's concerned.

"[35] Empire Online named it number thirty-four in a fan-voted "50 Worst Movies List", saying "Remember how great Lindsay Lohan was in Mean Girls?

Fangoria praised the film's imaginative use of color, saying "[T]he director and his visual team bathe the film in deep blues and reds, a welcome departure from the dirty green, sodium-lit palette of similarly themed horror fare, and the end result is simply a beautiful, eye-popping visual treat, so stylized that one can't help recalling Argento's approach to Suspiria.

"[40] The horror-movie website Bloody Disgusting gave the film a glowing review and suggested that, "Lohan's continual issues with drugs/alcohol/DUI’s/rehab/on-set bitchiness" were part of a "whirlwind of media frenzy" that was unnecessary and "irrelevant to the movie".

"[41] Boston Globe critic Ty Burr compared the film favorably to Brian de Palma's Sisters and Body Double, as well as the works of David Lynch.

[47] Years after its release, I Know Who Killed Me came to achieve cult status and was called a "midnight movie", as acknowledged by Sivertson during an interview in October 2019: "It definitely has.

[20] The film had frequently received screenings including at the Nuart Theatre, the Brattle Theatre, 92YTribeca, the 2013 San Luis Obispo International Film Festival, Alamo Drafthouse Cinemas and the Brooklyn Academy of Music, with the latter describing it as "deliriously, at times jaw-droppingly, perverse—exerting a strange fascination as a twisted mirror reflection of its troubled starlet's own downward spiral.

"[55] In January 2021, Charles Bramesco of The Guardian wrote that "this widely, wrongly maligned film has been embraced by a growing mini-cult attuned to its aesthetic of surreal artifice and grim interplay with real life."

He continued, "the baggage [Lohan] dropped off at set only served to deepen and enrich the subtext of a stealth noir gem, one that gestures to a long-bygone era of movie stardom through the framework of a cheaper and dirtier sort of serial killer thriller," and that, "As a girl next door seemingly transformed overnight into a vamp with a cigarette-rasped voice and formidable pole-dancing prowess, she brings the thought experiment of “what if Barbara Stanwyck had been fed through Disney's wringer as a child?” to life in exhilarating fashion.

"[13] While reexamining it for Splice Today, John Kidwell expressed that "on a metatextual level—specifically, as a film about the child star's painful transformation into sex symbol—I Know Who Killed Me is surprisingly self-aware and, at times, even intelligent.

"[56] In October 2021, Screen Slate announced they would be screening I Know Who Killed Me for its annual Scream Slate at the Roxy Cinema Tribeca and considered "modern audiences have also found it to be a genuinely thrilling example of a film that dares to be stylish, oblique, and extremely weird, like a sleazy update of Italian gialli plopped into the 2007 summer blockbuster season," adding that, "In further light of reevaluation of the way young women stars were mistreated and publicly vilified at the time, I Know Who Killed Me is a fascinating lens through which to revisit the 2000s.

"[57][58][59] That same month, screenwriter Jeff Hammond was interviewed about the film's newfound popularity and legacy, analyzing, "Its contradictions exist on multiple levels and most of them were intentional.

And I think that's part of the reason why people are still talking about it all these years later," and contemplated writing a sequel, "I've been catching myself pondering the fate that might await Aubrey and Dakota as adults.

[63] In October 2023, IndieWire named I Know Who Killed Me one of the best giallo movies of all time, asserting that "the movie holds up as a shockingly scary and stylish watch today" after being "divorced from [the] vicious media spectacle" it was subjected around its release, as "the premise makes for a twisty, genuinely surprising mystery, and Sivertson's direction is crisp, stylish, and always weird.