Hillary Scott, Charles Kelley and Dave Haywood, who comprise Lady Antebellum, co-wrote the song with Tom Douglas.

"I Run to You" is the group's first number-one single, reaching that peak in July 2009, and it features lead vocals from both Scott and Kelley.

In it, the narrators — lead singers Charles Kelley and Hillary Scott — claim that they turn to each other to escape the negativity and prejudice of the world.

Brady Vercher of Engine 145 gave the song a "thumbs down" review, calling it "a vague profession of love" and adding, "The song comes across as purposefully cryptic because they either didn’t fully develop the idea, haven’t become comfortable opening up in their lyrics, or they just didn’t feel the need to focus on the lyric other than as a device to support the melody.

"[4] Dan Milliken of Country Universe gave the song a B rating, saying that it "rolls sweetly along and never tries to sound more important than it really is".

[5] Paul Worley, who co-produced the album and played guitar on it, said, "The song is an expression against hate, prejudice, negativity, running the rat race, but ultimately the redemption of love!

A second video for the European release of "I Run to You" was shot and debuted on their record label Parlophone's YouTube page on July 30, 2010.