Nelson and co-writer Kristine Johnson researched the problems facing adults with intellectual disabilities by visiting the non-profit organization L.A. GOAL (Greater Opportunities for the Advanced Living).

In danger of losing child custody, Sam gets advice from his friends and also hires a lawyer, Rita Harrison, whose absorption in her work, and neglect of her son, reveals she also struggles with her role as a parent.

Afterward, Lucy resides in a foster home with Miranda "Randy" Carpenter but tries to convince Sam to help her run away.

In attendance are Lucy's former foster family, Sam's friend group, and a newly single Rita with her son.

The Grammy Award–nominated soundtrack, consists of original music by John Powell and cover versions of songs by The Beatles.

When producers were unable to obtain the rights to the original tracks, they commissioned artists such as the Black Crowes, Nick Cave, Stereophonics, Eddie Vedder, Sheryl Crow, Sarah McLachlan, Rufus Wainwright, the Wallflowers, Ben Harper, the Vines, and Ben Folds to record the versions released.

[6] Audiences surveyed by CinemaScore gave the film a grade "A" on a scale of A to F.[7] A. O. Scott of The New York Times wrote that "I Am Sam is not a bad movie, and its intentions are unimpeachable.

Ebert also criticized the morality tale character of the movie, saying that "You can't have heroes and villains when the wrong side is making the best sense.

"[10] Kevin Thomas of the Los Angeles Times reviewed it positively as a "most inviting and accessible film that turns upon a mental condition that most people would prefer not to think about.