Jacopo Piccolomini-Ammannati, or Giacomo Piccolomini (8 March 1422 – 10 September 1479) was an Italian Renaissance cardinal and humanist.
He was retained in this office by Pope Pius II, who also made him a member of the pontifical household, on which occasion he assumed the family name of Piccolomini.
Ammannati exhibited paternal solicitude in the government of his diocese, and during his prolonged absences entrusted its affairs to able vicars, with whom he remained in constant touch.
The disfavor in which he was held by Paul II did not exempt his episcopal revenues from sequestration by the Duke of Milan, Galeazzo Maria.
Cardinal Bessarion (Pastor, Geschichte der Päpste, II, 731), praises his executive ability and readiness, charity and zeal.