He was elevated to the Carlton Football Club Senior list in 2001 and made his debut in Round 17, 2001 against Hawthorn.
The 2005 season saw Prendergast play just 13 games but there was an early high as he was part of the club's preseason premiership win over West Coast.
Perhaps his most memorable moment in a Carlton guernsey came in this game as he booted a nine-point super goal in the final quarter to effectively seal the win for the Blues.
Prendergast played only three games for Carlton in 2006, partly because the club was adopting a youth policy.
In 2012, he was a playing assistant coach with the University Blues in the Victorian Amateur Football Association.