Ayew began to play football at Adisadel College, and later started his professional career with his father's team F.C.
On 17 June 2009, after much speculation, then 21-year-old Ghanaian national player joined from Sekondi Wise Fighters to Egyptian giants El Zamalek FC, where he signed a five-year contract.
He became a free agent in July 2013 after a two-season stint with Lierse and then for 5 months, he tried to look for a team to play.
He was selected, together with his brother André Ayew as part of Ghana's 23-man team for the 2010 World Cup staged in South Africa.
He is the half brother of André, Jordan and Imani, having the same father, Ghana's renowned ex captain Abédi Pelé.