Cissé was born in Dreux, Eure-et-Loir, France,[2] in a family with Malian origins, with two of his elders brothers – Salif and Kalifa – who also embraced a professional footballing career.

[3] Cissé came through the youth ranks of La Berrichonne de Châteauroux in his native region, before moving to Gent in 2019.

[2] Cissé made his professional debut for Gent on the 9 December 2021, replacing Michael Ngadeu-Ngadjui at the 62nd minute of a 1–0 Europa Conference League home win against FC Flora.

[4][5] On 3 May 2022, Cissé agreed to join Schalke 04 on a free transfer for the 2022–23 season, signing a four-year contract.

Cissé received his first call up to the senior team for the Africa Cup of Nations qualification in October 2024.