Born and raised in the Bronx, New York City, she began her musical career during college in 2020, after meeting record producer RiotUSA.

[3] Ice Spice gained major recognition in late 2022 with her song "Munch (Feelin' U)", which went viral on TikTok.

After signing with 10K Projects in a joint venture with Capitol Records, she released the singles "Bikini Bottom" and "In Ha Mood" to promote her debut extended play (EP), Like..?

2" (with PinkPantheress), "Karma" (with Taylor Swift), and "Barbie World" (with Nicki Minaj and Aqua), all of which peaked within the top-ten of the Billboard Hot 100.

In an interview with Billboard, Isis explained that she grew up listening to the likes of Jay-Z, 50 Cent, and Wu-Tang Clan because of her father's rap background.

[18] Gaston attended State University of New York at Purchase, where she was a defensive specialist on the school's volleyball team and studied communications.

[22] Around her sophomore year, Gaston dropped out of SUNY Purchase, later explaining that she did not believe the school was the right fit for her, and attributing her leaving college to the "strenuous commute".

[24] He produced her debut song, "Bully Freestyle", released in March 2021 after a video of Ice Spice doing the "Buss It" challenge went viral on Twitter.

[26] On August 10, 2022, Ice Spice released her song "Munch (Feelin' U)", accompanied with a video distributed by WorldStarHipHop,[27] as the lead single from her then-untitled debut EP, Like..?.

[32] Ice Spice's debut EP, Like..?, was released on January 20, 2023, and included the singles "Munch (Feelin' U)", "Bikini Bottom", and "In Ha Mood".

[33] In February 2023, Ice Spice collaborated with Lil Tjay on the tribute single "Gangsta Boo" to the late rapper of the same name, which became her first song on the Billboard Hot 100 at No.

[45] The project received mixed reviews from fans and critics, with Variety noting Ice Spice's contribution to the drill subgenre, stating that Y2K!

"struck the right equilibrium between street and pop sensibility — just hard enough for rap purists, softened around the edges for broader appeal — and set the table for what was leaning toward a mainstream breakthrough with her debut album."

[49] On New Year's Eve of 2024, Ice Spice arrived 25 minutes late to her Wildlands Festival set in Brisbane.

"[55] Ice Spice was first inspired to start rapping by Sheff G and Pop Smoke, and has listed Lil' Kim, Nicki Minaj, Cardi B, Foxy Brown, and Remy Ma as musical influences due to their New York roots.

[13][11][14] She has also called Erykah Badu, Rihanna, Taylor Swift, and Lauryn Hill inspirations because of their "graceful angelic vibe of timeless beauty".

The feud gained internet attention in January 2023 when fans interpreted a lyric from "Princess Diana" off of her EP "Like..?

[58] A year later, the feud began to escalate after Latto released a snippet of her then-unreleased song "Sunday Service", where the music video for Ice Spice's song "Pretty Girl" could be seen on the TV in the background; just hours later; Ice Spice released a snippet of her own unreleased diss track by the name of "Think U the Shit (Fart)".

The controversy garnered significant public attention, with artists Baby Storme and Azealia Banks voicing their support for Cleotrapa.