Patients who have multiple idiopathic effects that are nonspecific are more likely to have anxiety and depression.

In adverse drug reactions involving overdoses, the toxic effect is simply an extension of the pharmacological effect (Type A adverse drug reactions).

The proposed mechanism of most idiosyncratic drug reactions is immune-mediated toxicity.

To create an immune response, a foreign molecule must be present that antibodies can bind to (i.e. the antigen) and cellular damage must exist.

The second criterion of cellular damage can come either from a toxic drug/drug metabolite, or from an injury or infection.