He played college football at Northwestern and was selected by the Minnesota Vikings in the seventh round of the 2017 NFL draft.
He was selected by USA Football to the 2012 U.S. Under-19 National Team and also competed in the Under Armour All-American Game and International Bowl.
As a true freshman, he only appeared in a game against Vanderbilt before suffering a season-ending injury, but was granted hardship waiver and did not lose a year of eligibility.
The next season, he saw time on the field as a third-down pass-rushing specialist and finished second on the team with 5.5 sacks.
[5] In week 5, Odenigbo tallied 4 of the Wildcats' 6 total sacks against Iowa, tying the school record in the 38–31 victory.
Odenigbo ended his collegiate career ranked second in Northwestern school history with 23.5 sacks.
In Week 5, he got his first career sack, tackling Daniel Jones in a road win against the New York Giants.
[20] In Week 17 against the Chicago Bears, Odenigbo recorded a strip sack on Mitchell Trubisky and recovered the football during the 21–19 loss.
[27] In Week 14 Odenigbo recovered a fumble forced by Takkarist McKinley in a 24–22 win over the division rival Baltimore Ravens.