Nawab Iftikhar Hussain Khan of Mamdot (31 December 1906 – 16 October 1969) was a Pakistani politician and an advocate of the Pakistan Movement in British India.

[1] On the death of his father in 1942, he succeeded him as the Nawab of Mamdot and on inheriting his lands became the largest landowner in the Punjab.

[4][1][10] Having foregone his constituency in Firozepur district and extensive estates in East Punjab, Mamdot sought to rebuild his powerbase in Pakistan.

[2] His stance, together with his refusal to cooperate with the centrally appointed Pakistan and West Punjab Refugee and Rehabilitation Council led to the resignation of Iftikharuddin, providing a free hand to Mamdot to allocate evacuee properties as he wished.

Aside from conflict with Iftikharuddin and Ghazanfar Ali Khan, head of the Refugee and Rehabilitation Council, he clashed with Mumtaz Daultana and Sir Francis Mudie.

[12] It was alleged he used public funds to personally acquire about 2,000 acres of prime agricultural land at nominal rates in Montgomery District, that he awarded to his brother several hundred acres of land in the same district that belonged to Sir Khizar Hayat Tiwana and that he secretly deposited over 100,000 rupees from the Kashmir fund into his brother's account.