The Igapó-Açu Sustainable Development Reserve is divided between the municipalities of Manicoré (21.9%), Borba (21%) and Beruri (57.1%) in the state of Amazonas.

In the southeast it adjoins the Rio Amapá Sustainable Development Reserve and the Nascentes do Lago Jari National Park.

[3] The Igapó-Açu Sustainable Development Reserve was created by Amazonas state decree 28420 of 27 March 2009.

[4] The conservation unit, and five others, were formed as part of a plan to form a "green barrier" along the BR-319 highway, which links Porto Velho to Manaus, so as to contain the advance of agriculture and predatory extraction of natural resources in the south of Amazonas.

[3] On 16 November 2009 the Instituto Nacional de Colonização e Reforma Agrária (INCRA – National Institute for Colonization and Agrarian Reform) recognised the reserve as supporting 200 families, who would qualify for PRONAF support.