Many illustrious people of Havana were baptized in this church, among them the educator José de la Luz y Caballero.

[citation needed] The Iglesia del Espíritu Santo's greatest interest from an architectural point of view lies in the simplicity of the coral stone construction and the lack of lavish decoration.

The building was built in the "uni-nave" style, as pointed out by Joaquín Weiss, a Cuban architect, and historian and one of the most authoritative authorities on the subject.

The elliptical arch supported by matching pilasters at opposite walls date from 1808 which is the year of the construction of the bell tower.

In the middle of the 19th century, the entire wall that faces Acosta Street was rebuilt and the main façade was remodeled.

The three-story bell-tower was built in the year 1808 and it is located immediately to the left of the church upon entering, it is one of the tallest structures in Old Havana.