[1] Mesa studied in Seville where the Order of Saint Augustine oversaw her education; she resided with her maternal grandmother at this time.

[2] Her grandmother also granted her permission to join the Third Order of Saint Francis and this saw her parents start to relax their religious restrictions on their daughter.

The Mesa's later relocated to Mexico at the end of 1904 due to tough economic conditions and it was there that she joined the Little Sisters of the Abandoned Elderly on 12 July 1908.

Cortesi met her on 15 August 1924 and gave her an image of the Blessed Virgin Mary as a token of goodwill and because it was the Feast of the Assumption.

Mesa left the order on 16 June 1925 to found a new religious congregation and rallied ten Bolivian women to join her in this effort while Cortesi approved the initial blueprint on 18 August 1925 while later discussing it more with her at length later that same week.

[1] Mesa travelled to Madrid in 1935 where she founded a home for the spiritual exercises to be run but left due to the dangerous and anti-religious Spanish Civil War.

The Congregation for the Causes of Saints later validated the diocesan process on 20 February 1987, in Rome and received the official Positio dossier from the postulation in 1987.

Pope John Paul II approved that Mesa had lived a life of heroic virtue and named her as Venerable on 1 September 1988.

John Paul II approved that the healing was, indeed, a miracle on 7 March 1992, and beatified Mesa in Saint Peter's Square on 27 September 1992.

Pope Francis confirmed the healing to be a legitimate miracle on 26 January 2018; her canonization was celebrated in Saint Peter's Square on 14 October 2018.

[4] The supposed miracle that could have led to canonization was investigated and then validated on 12 December 2003 though could not proceed further because the medical board disapproved of this in their meeting held on 3 July 2008.