Ignacio Antinori (February 17, 1885 – October 23, 1940)[1] was an Italian-born American mobster who built one of the earlier narcotics trafficking networks in Florida.

Although much of his early life is unknown, Antinori was one of the first mobsters to emerge in Florida during the Prohibition era.

According to the Federal Bureau of Narcotics, the drugs were subsequently distributed in the Midwestern United States, primarily through St. Louis mobster Thomas Buffa and Kansas City mobsters Nicola Impastato, James DeSimone and Joseph Deluca.

On October 23, 1940, Ignacio Antinori was sipping coffee at the Palm Garden Inn in Tampa with a friend and a young female companion.

Suddenly, a gunman appeared and fired two shotgun blasts at Antinori, blowing off the back of his head.