[1] Guadalupe debuted as an actor in the television series Mein Freund Winnetou in 1980.

He later made his film debut in Vidas errantes, he was nominated for an Ariel Award for Best Actor and won a Diosas de Plata Award for Best Newcomer for his performance in the film.

Besides this, he also worked as a writer for the television show La hora marcada.

[2] In 1990, Guadalupe participated in Pueblo de madera, his performance earned him a nomination for the Ariel Award for Best Supporting Actor.

[3] Since, Guadalupe has acted mainly in television, participating in telenovelas and TV series, but also in films: most notably in The Three Burials of Melquiades Estrada in 2005 and For Greater Glory in 2012.