According to a statement in his handwritten memoirs[2] he was a pupil of both Wolfgang Amadeus Mozart and Johann Georg Albrechtsberger.
He edited Albrechtsberger's complete written works after his death, published by Tobias Haslinger.
His own pupils included Franz von Suppé, Heinrich Wilhelm Ernst, Antonio Casimir Cartellieri, Joseph Fischhof and Eduard Marxsen who would later teach Johannes Brahms.
In his youth Seyfried served as the assistant conductor for Emanuel Schikaneder's opera troupe at the Theater auf der Wieden in Vienna, becoming musical director in 1797 and serving (in its new building, the Theater an der Wien) until 1826.
"[citation needed] He made arrangements of Beethoven's Three Equals for four trombones, WoO 30, for four-part men's chorus, performed at Beethoven's funeral; re-scored Michael Haydn's Deutsche Messe, for men's voices only;[7] and arranged over twenty operas by others for various wind band combinations.