In 2002–03, Grigorenko was the leading scorer with Lada in the Russian Super League with 19 goals and 29 points in 47 regular season games.

In addition, complications arose and he developed a fat embolism in his left lung, which is a potentially fatal condition.

He signed a one-year, entry-level contract with the Detroit Red Wings in May, 2007, but was unable to make the team out of training camp.

After 5 games in the American Hockey League with affiliate the Grand Rapids Griffins, Grigorenko returned to Russia.

During the 2012–13 season, after scoring 5 points in 12 games, Grigorenko was traded from to Salavat Yulaev Ufa to CSKA Moscow in exchange for Denis Parshin on October 10, 2012.