The founder of the dynasty of artists was Galeazzo Pesenti Seniore, also called Il Sabbioneta, active in the 15th century in Cremona.
A painting of the Virgin with Saints Gregory and Bartholomew (1557) found in parish church of Spigarolo oltre Po, was attributed to Francesco.
An Adoration of the Magi at Sant'Agostino, Cremona was signed Franciscus Sabloneta Cremonenesis.
He also designed a funereal catafalque for Senator Ala, and the triumphal arch for the arrival of Archduke Rudolf to Cremona on December 21 of 1563.
He helped create the decoration for the Palazzo del Giardino in Sabbioneta, working under Bernardino Campi.