The UIS Prairie Stars (also Illinois Springfield Prairie Stars and formerly Sangamon State Prairie Stars) are the athletic teams that represent the University of Illinois Springfield, located in Springfield, Illinois, in intercollegiate sports as a member of the Division II level of the National Collegiate Athletic Association (NCAA), primarily competing in the Great Lakes Valley Conference (GLVC) since the 2009–10 academic year, which they became a full-fledged Division II member on Aug. 1, 2010.

The Prairie Stars previously competed in the American Midwest Conference (AMC) of the National Association of Intercollegiate Athletics (NAIA) from 2003–04 to 2008–09.

[3] The Prairie Star men’s basketball program started in 2002 under the direction of head coach Kevin Gamble, a 10-year NBA veteran who played six seasons for the Celtics.

The program earned back-to-back postseason berths by winning the AMC tournament titles in 2006 and 2007, defeating McKendree in the championship game in both seasons.

The Prairie Stars lost an opening round game to Benedictine (Kan.)[6] The university joined the American Midwest Conference in 2003.

The NAIA started team play for tennis in 2000 and the Prairie Star women's program advanced to the national tournament in 2000 and 2004.