It runs from the Norbert F. Beckey Bridge across the Mississippi River where it meets the eastern end of Iowa Highway 92, east to U.S. Route 34 in La Moille.

[1] It is part of a continuous 886-mile (1,426 km) four-state "Highway 92" which begins in Torrington, Wyoming, goes through Nebraska and Iowa and before terminating in Illinois.

After Andalusia, it turns northward, becoming the Centennial Expressway, intersecting Interstate 280 and entering Downtown Rock Island.

In Downtown Moline, it intersects concurrent Interstate 74 and U.S. Route 6 at the east bank end of the I-74 Bridge over the Mississippi.

It traverses the rich Illinois farmland, crossing the Rock River and the historic Hennepin Canal.