[3] She was employed as a social worker, and ran a community centre in Yafa an-Naseriyye.

[3] A member of the Southern Branch of the Islamic Movement and its political wing, the United Arab List, Khatib-Yassin was placed ninth on the United Arab List–Balad list for the April 2019 elections,[4] but the alliance won only four seats.

On 5 November 2023 Khatib-Yassin said that the attackers of the 7 October Hamas-led attack "didn't slaughter babies and they didn't rape women, at least not in the footage" of a 43-minute video made by the Israeli Defense Forces and shown to members of the Knesset, but "If [such actions] happened, it’s shameful".

Her remarks prompted United Arab List leader Mansour Abbas to call on Khatib-Yassin to resign from the Knesset.

Later the same day, Khatib-Yassin apologised, saying "I had no intention to belittle or deny the shocking massacre on October 7th and the terrible acts against women, babies, and the elderly who were murdered in the South."