Chicanes were introduced at multiple points to reduce cornering speeds, which changed the nature of the course and caused problems with their high kerbs.

Formula One stopped racing at Imola in 2007, leading the circuit owners to undertake major reconstruction work to the track and pit lane facilities.

When Formula One visits Imola, it is considered one of the home circuits of the Scuderia Ferrari racing team, which is based in nearby Maranello.

It was the first time since the 1948 Edition held at Parco del Valentino that the Autodromo Nazionale Monza did not host the Italian Grand Prix.

The track was also used as part of the finishing circuit for the 1968 UCI Road World Championships, which saw Italian cyclist Vittorio Adorni winning with a lead of 10 minutes and 10 seconds over runner up Herman Van Springel, the second largest winning margin in the history of the championships, after Georges Ronsse's victory in 1928.

Despite the addition of chicanes to several parts of the lap, such as the Acque Minerali, Variante Alta, and Variante Bassa, the circuit was subject to constant safety concerns, mostly regarding the flat-out Tamburello corner, which was very bumpy and had dangerously little room between the track and a concrete wall without a tyre barrier that separated the circuit from the Santerno river that runs adjacent to it.

The car instantaneously ignited after the severe impact at 300 km/h (190 mph) but thanks to the quick work of the firefighters and medical personnel Berger survived and missed only one race (the 1989 Monaco Grand Prix) due to burns to his hands.

In response to the deaths of Ayrton Senna and Roland Ratzenberger during the 1994 San Marino Grand Prix, modifications were carried out to the Tamburello corner to make it safer by converting it from a flat-out left hander to a left-right-left chicane.

In the 1994 San Marino Grand Prix, during Friday practice Rubens Barrichello was launched over a kerb and into the top of a tyre barrier at the Variante Bassa, knocking the Brazilian unconscious, though quick medical intervention saved his life.

During Saturday qualifying Austrian Roland Ratzenberger crashed head-on into a wall at over 310 km/h (190 mph) at the Villeneuve corner after his Simtek lost the front wing, dying instantly from a basilar skull fracture.

The tragedy continued the next day when the three-time World Champion Ayrton Senna's Williams' steering column broke and he crashed into the concrete wall at the Tamburello corner on Lap 7.

In the aftermath, the circuit continued to host Grands Prix, but revisions were immediately made in an attempt to make it safer.

[8][9] Another modification made to the Imola track is that of Variante Alta, which is situated at the top of the hill leading down to Rivazza and has the hardest braking point on the lap.

[13] In June 2015, the owners of the circuit confirmed they were in talks to return to the Formula One calendar should Monza, whose contract was scheduled to run out after the 2016 season, be unable to make a new deal to keep hosting a round of the world championship.

[18] In February 2020, the owners at Imola submitted a bid to replace the 2020 Chinese Grand Prix pending its cancellation as a precaution in the face of the COVID-19 pandemic.

[25] Among the major musical performances held on the track were: Partially due to the vicinity of the Romeo Galli athletics stadium, the Acque Minerali park, and the Tre Monti hills, the Autodromo is not commonly used for bicycle or on-foot sporting activities (albeit with notable exceptions, such as two segments of the Giro d'Italia in the 2010s, and 2020 UCI Road World Championships); however, the civic administration does occasionally allocate summer days in which the public can walk or cycle along the track.