Born in Valladolid, Sastre's career started at the age of 12, when she was selected for a fast-food commercial with McDonald's.

She studied at The Sorbonne in Paris, and in addition to Spanish, she speaks French, English and Italian fluently.

[3] In 1997, before playing the role of Francesca Babini in Italian director Pupi Avati's movie Il testimone dello sposo, she became the Beauté Naturelle for having won the Prix de la mode in Paris' Fashion Awards.

In 2000, Sastre achieved popularity in Italy as a presenter with Fabio Fazio at the Italian Music Festival di Sanremo.

She enjoys golf and has played in the Gary Player Invitational charity pro-am several times in South Africa to help raise funds for needy children.