In Enemy Hands is a 2004 American submarine film directed by Tony Giglio and starring William H. Macy, Til Schweiger, Thomas Kretschmann, Scott Caan and Lauren Holly.

The movie begins with old film footage of World War II with a narrator explaining that Germany produced hundreds of U-boats to control the Atlantic.

Meanwhile, the U-429 (a fictional U-boat based on the real U-429), captained by Jonas Herdt (Schweiger) survives a depth charge attack by an American destroyer, after which U-429 sinks the ship.

After playing chess with his First Watch Officer Ludwig Cremer (Kretschmann), Jonas receives a message from home, informing him that the German city of Hamburg got bombed.

On the Swordfish, XO Teddy Goodman (Gregg) becomes increasingly sick with a rash on his stomach, which the doctor believes is meningitis, an extremely contagious disease that can sometimes be fatal.

Radio operator Virgil Wright (Huntington) hears music played by Glenn Miller coming from the U-821, and Sullivan prepares the crew to attack.

Sullivan, Travers, and six other crew members Wright, engineers Abers (Sisto), and Ox (Gallagher), and torpedomen Miller (Somerholder), Cooper (Giovinazzo), and Romano (Morgan) abandon ship and are taken prisoner by the nearby U-429.

The Germans split their prisoners into two groups: Travers, Ox, Cooper, and Miller in the bow and Sullivan, Wright, Abers, and Romano in the stern.

Wright nurses Sullivan and discovers his rash, where Abers recognizes it as meningitis, and the group realizes that if the Germans don't kill them, the disease will.

During their travel to the United States coast, Klause (Heger), the U-429's quartermaster, becomes disillusioned with Jonas working with the Americans and orchestrates a mutiny, along with two other crew members, Lieutenant Bauer and the U-429's radio operator Christophe.

Abers and Wright subdue Christophe, who makes a distress call to other U-boats, and engineer Hans (Thorsen) knocks out Bauer to save Ox.

Enduring heavy damage as they evade every torpedo attack, two German crew members try to convince Cremer to fight back, but he refuses to fire on his own countrymen.