[2] Featuring original interviews with famous sporting-world figures Wayne Gretzky, Jerry Rice, and Pelé, In Search of Greatness explores the role of creativity in the careers of the world's greatest athletes, both historical and contemporary.

Some well-known sports personalities spotlighted in the film are Serena Williams, Tom Brady, Muhammad Ali, Rocky Marciano, Red Auerbach, and Michael Jordan.

A number of major cultural figures' careers are also highlighted for comparison to those of top athletes, including The Beatles, David Bowie and Jimi Hendrix.

In April 2018, The Hollywood Reporter published an article upon the release of the film's first trailer, calling In Search of Greatness "an early contender for the best documentary feature Oscar.

[4] During an April 2018 interview with Sports Illustrated discussing what inspired the film, Polsky said "Every boy and girl has their own variables, their own creative abilities.