Independence, originally known as Uncle Sam,[4] is a town in Tangipahoa Parish, Louisiana, United States.

[7] A strong promoter of his hometown of Independence, located five miles to the south of Amite, Wilson in 1902 and 1903 corresponded with Governor William Wright Heard regarding incorporation of the community, which at the time had a population of 308.

Governor Heard informed Wilson that he considered the three square miles proposed for the new town as too much land for a small village and suggested that the tract be reduced in size.

Originally named "Uncle Sam", Independence had begun in 1852 when the New Orleans, Jackson and Great Northern Railroad began operating through the area.

[6] According to the United States Census Bureau, the town has a total area of 2.2 square miles (5.7 km2), all land.