Founded in 1958, the club plays its home games at Estadio Banco Guayaquil, which opened in March 2021 and has a capacity for 12,000.

[4] Some well-known footballers the club has produced are Jefferson Montero, Junior Sornoza, Arturo Mina, Cristian Ramírez, Gonzalo Plata, Moisés Caicedo, Piero Hincapié, Willian Pacho and Kendry Páez .

After winning the Segunda Categoría in 2007, the club changed its name to Independiente del Valle and adopted the current colors (blue and black).

[6] Independiente del Valle unexpectedly reached the finals of the 2016 Copa Libertadores with incredible odds,[7] being compared to Leicester City's Premier League title that same year.

[8][5] Independiente began its knockout stage run by beating Copa Libertadores defending champions, Argentina's River Plate, in the round of 16 2–1 on aggregate.

[9] The club subsequently faced Argentina's giant Boca Juniors in the semi-final, defeating them 5–3 on aggregate, including a 3–2 victory at the famous La Bombonera stadium.

Independiente's fairy tale story came to a conclusion after a 1–0 loss in the second leg with the series ending 2–1 in favor of the Colombians.

It was considered a major upset because Colón had a richer history and a much bigger fanbase, with around 40,000 fans at the stadium versus only 500 Ecuadorians.