Acharya JB Kripalani, who was then President of the Indian National Congress inaugurated the Founding conference of INTUC.

Among the distinguished leaders who attended the opening session were Pandit Jawaharlal Nehru, Shankarrao Deo, Jagjivan Ram, B. G. Kher, OP Mehtab, Aruna Asaf Ali, Ram Manohar Lohia, Ashoka Mehta, Ramchandra Sakharam Ruikar, Maniben Patel and other prominent trade unionists.

On several occasions there have been discussions over the relationship between INTUC and AICC and the need for having continuous dialogue between the two organisations on issues of mutual interests.

Similarly during 2002, an advisory committee was formed under the chairmanship of Pranab Mukherjee.

On behalf of INTUC, G. Sanjeeva Reddy president, then general secretary and two vice-presidents represented.