The India cricket team toured South Africa from December 2021 and January 2022 to play three Tests and three One Day International (ODI) matches.

[20] The tour was also scheduled to include four Twenty20 International[21] (T20I) matches, but these were postponed,[22] with Cricket South Africa saying these would be "rescheduled for a more opportune time".

[24] In December 2021, it was announced that South Africa's Quinton de Kock would miss at least the third Test of the tour due to him taking paternity leave.

[34] India also named Navdeep Saini, Saurabh Kumar, Deepak Chahar and Arzan Nagwaswalla as standby players in their Test squad.

[35] Rohit Sharma was ruled out of India's squad for the Test matches due to an injury,[36] with Priyank Panchal named as his replacement.

[40] Ahead of the ODI series, Washington Sundar was ruled out of India's squad following a positive test for COVID-19, with Jayant Yadav named as his replacement.