On the west side of South Bend, SR 2 ends at an interchange with US 20 and U.S. Route 31 (US 31).

SR 2 appears to be part of an old alignment from Kankakee, Illinois, to South Bend and runs more diagonally than other east–west state highways in Indiana.

In Valparaiso, SR 2 has been rerouted around the downtown and central business districts of the city.

Until the completion of the St. Joseph Valley Parkway around the South Bend – Elkhart area, SR 2 continued to downtown South Bend, mostly along Western Avenue (which remains, but no longer has state highway markers).

SR 2 originally followed the Lincoln Highway to Fort Wayne before U.S. Route 33 (US 33) supplanted it east of downtown South Bend.