The highway passes through rural areas of Carroll and Howard counties, before ending in Kokomo.

The entire road covers a distance of about 45 miles (72 km), passing through mostly rural areas.

In the late 1930s SR 22 was moved to a new alignment between Hartford City and the Ohio state line.

On its way to Kokomo SR 22 passes through rural Carroll and Howard counties before an intersection with Malfalfa Road.

The SR 22 designation ends at this intersection but the roadway continues east towards downtown Kokomo as Sycamore Street.

SR 22 heads due east concurrent with US 35, passing through agriculture properties.

The highway enters Greentown passing through downtown before an intersection with the northern end of SR 213.

The road has an intersection with SR 9, before curving northeast, passing just north of Jonesboro.

East of the river Main Street cross a railroad track and enters downtown Gas City.

Past I-69, SR 22 leaves Gas City entering rural Grant County, passing farms and fields.

The road has an intersection with the southern end of SR 5 before curving to become north-south and entering Upland.