The highway heads north then turns eastwards, passing through Ambia, Boswell, and Oxford before ending at U.S. Route 52 (US 52), near Templeton.

The road covers a distance of about 20 miles (32 km), passing through mostly rural areas in Benton and Warren counties.

In town the road passes through residential areas and crosses a Kankakee, Beaverville and Southern Railroad track.

[3][4] After US 41, SR 352 leaves Boswell, heading east towards Oxford, passing through farmland and parallel to the Kankakee, Beaverville and Southern Railroad track.

SR 352 heads south concurrent with Michigan Street for a block before turning east and leaving Oxford.

The eastern end of SR 352 is at an intersection with US 52, northwest of Templeton, the roadway continues east as Benton County Road 600 South.

The lowest traffic count on SR 352 is south of Ambia, where 200 vehicles travel the highway on average each day.

[11][12] SR 352 commissioned between Illinois state line, northwest of Ambia and Boswell, passing through Handy and Talbot, between 1937 and 1938.